Descemet Membrane Endothelial Keratoplasty (DMEK) represents the latest evolution of corneal endothelial transplantation. This challenging technique offers minimal incision size, faster healing, better visual outcomes, and the lowest rejection rate of any corneal transplant modality. The surgeons at Price Vision Group perform hundreds of DMEK surgeries every year with some of the best published results in the scientific literature. In this interactive journal they take you into the operating room and teach their pearls for success in a step-by step fashion. The Digital Manual of Ophthalmic Surgery and Theory is a new interactive series that will present innovative surgical and medical treatments in the field of Ophthalmology from international thought leaders.